Vitamin B2

International generic name

Riboflavin

Drug form and composition

Solution for injection. One ampoule of 2 ml contains Riboflavine Sodium Phosphate equ. to 10 mg Riboflavin (5 mg/ml).

Indications

Lack of vitamin B2, when oral treatment is not enough effective in following conditions: burning; chronic febrile states; gastrectomy; liver and biliary ducts diseases (alcoholism with cirrhosis, obstructive jaundice), hyperthyroidism; prolonged infections; intestinal diseases (tropical sprue, enteritis, persistent diarrhea); malignant tumors; prolonged stress.

Dosage and administration

The drug is used by parenteral route (intramuscularly or intravenously) in a daily dose - 5 to 20 mg. The treatment course depends on the severity of the disease. After getting control of the clinical picture the treatment can be continued by oral drug administration.

Contraindications

Hypersensitivity to the preparation.

Special warnings and precautions

Because of different types of incompatibility, administration in one syringe is unallowable with: benzylpenicillin and oxacillin (antibiotic inactivation and precipitation); macrolides (formation of unsoluble sediment); chloramphenicol (precipitation); vitamin B1 (vitamin B1 oxidation); vitamin B12 (vitamin B2 destruction by the cobalt ions); vitamin C (vitamin B2 inactivation).

Drug interactions

No clinically significant adverse drug reactions in cases of concurrent administration of vitamin B2 with other drugs have been reported.

Adverse reactions

In some cases, pain in the place of drug application can be observed. After administration of high doses hypergranulate (changes in oral mucosa) can occur.

Pharmacological mechanisms

Vitamin B2 is widespread in the nature. It has also been produced synthetically. The vitamin enters in the body predominantly with the food (beer, liver, eggs, meat, fish, milk, wheat germs, etc.) It plays role in the oxidation-reduction reactions in the body. After entering in the organism vitamin B2 interacts with adenosine triphosphate acid and forms nucleotide compounds, which represent coenzymes of flavin proteins, participating in the transmission of the hydrogen ions and in the regulation of the oxidation-reduction reactions. It facilitates carbohydrate metabolism, improves disturbed lipid metabolism, and it is related to the metabolism of the amine acids. Vitamin B2 influences the iron and porphyrin metabolism, hemoglobin synthesis, and cellular breathing.

Supplied

10 or 100 ampoules of 2 ml (10 mg).

Norefal cell therapy

Norefal cell therapy technique is organ specific, that is the cell of a particular organ is used to revitalize the cell of the like organ e. G. When the cells implanted originated from the thymus glands of the donor, it will find its way to the thymus glands of the recipient. Thus, heart to heart & liver to liver. This landmark research in the 1970's, at the university of heidelberg, demonstrated by radioactive marking and tracing of cells proved that cellular material was indeed transported by the human host's blood to counterpart organs and tissues.

Researches also discovered that when new cells are added, they have stronger resonant (vibration) to induce the old and weak or any damage cells to re-vibrate to the same frequency as the young healthy cells again. As a result, there is restoration and renewal of cells

The major benefit of norefal cell therapy is, noticeable rejuvenation of skin and increased vitality in life is experienced once the patient undergoes the cell therapy. Your face will also look younger and healthier in texture and color while your body will be physically fitter and more flexible.


In addition to general body revitalization, health maintenance and life extension, cell therapy will effectively stimulate the cells of specific organ systems concerned with obesity, arthritis, chronic fatigue, asthma, degenerative brain disease, osteoporosis, circulatory disturbances, sexual dysfunction, male impotence, diabetes mellitus, hormonal disturbances, skin eruptions and many other metabolic diseases.

Your body immune system and defense mechanisms can be revitalized. When too many damaged cells make up the various tissues and organs involved in the immune system, the body becomes defenseless against both external invasion and internal degeneration. Thus, cell therapy is used to restore the damage immunity cells.

Biotad and Biotad Glutathione

The new glutathione has arrive. the product name is
BIOTAD 5x5ml from Italy Biomedica Foscama s.p.a.
ingredients: vitamina C bioflavonoid and glutathione
extract. Apart from being an anti oxidant for the body
system by removing free radicals and toxic it is also
good in skin whitening and firming. the advantage of
this product compared to other glutathione injection
is that it contains vitamin C which will give the
whitening effect to the skin, and the glutathione
extract will help the whitening process of the skin by
optimising the usage of vitamin C inside the body
system.


COMPOSITION:

BIOTAD 300

5 frozen-dry Flacone contains of reduced gluthatione 300mg
5 dissolvent Vials bioflavonoid for I.M/E.V
preparations 500mg/5ml

Name and address of authorization:
Via Morolense, 87 - 03013 ferentino (FR) - Italy
What is Glutathione?

-it is a protein (amino acid) molecule which is important as our body antioxidant, immune system booster and detoxifier
-it presents in every cell to promote normal function as maintaining the immune system
-one of the master antioxidant that mostly found in liver
-it eliminates toxic compound (such as Paracetamol) in liver
-it reconstitutes vitamin C and E which is being oxidized
-combine taking with vitamin c injection greatly enhance your immunity, reduces tiredness, more youthful skin and stay healthy
-fights against the cancer, heart disease, premature aging, autoimmune disease and chronic illness

Dosage and method of Administration:

Diluted 300mg glutathione -
1 ampoule weekly by intravenous or intramuscular method.

Overdose: Not reported

Mode of conservation: Not to be used if expiry date on the box is exceeded

Interaction:

No known interaction, individual with liver malfunction is not supposed to take this product. Pregnant and lactating women are not supposed to take the injection and other same kind of supplementary.

Frequently Asked Questions:

1. What is glutathione?

It is an important chemical that acts as a powerful antioxidant to preserve and protect the brain and other body tissues by protecting them from the damage of free radicals. It also acts to recycle vitamin C & E which also reduce free radicals.
2. What studies prove it work or are there any studies that prove it works?

The landmark study was done by the Department of Neurology, University of Sassari , Italy in 1996. In this study all patients improved significantly after glutathione therapy with a 42% decline in disability.

3. What is glutathione used for?

It has been used to treat all symptoms of neurodegenerative diseases such as Parkinson's, Alzheimer's, multiple sclerosis, stroke, ALS, irritable bowel, and chronic fatigue.

4. What improvement in symptoms can one expect?

Many patients have had profound improvements with respect to reduction of rigidity, increased mobility, improved ability to speak, less depression, and decreased tremor. Glutathione has the added benefit of protecting the brain from free radical damage, thus possibly slowing the progression of the underlying illness.

5. How long can a person take glutathione and how long will the effect last after I stop using it?

It can be taken permanently. In the 1996 Italian study the therapeutic effect lasted 2-4 months after therapy was stopped.

6. How long has this treatment been used?

Physicians have been using glutathione infusions for at least 30 years, probably longer.

7. How is the treatment given?

It is given IM or intravenously in the arm by IV push over 10 to 15 minutes usually three times a week in a physician's office.

Injection method:
-Intravenous (IV) by drip or normal injection.
-Drip took 15~45 minute will be best effect.

Side effect:
-Do not use more than 20g vitamin per day, it may cause digestion disorder (diarrhea & gastric pains)

Vitamin E Sanum

Good for skin n health. The main function of this product is ANTI-OXIDANT. It's good for whitens the skin and helps prevent skin ageing.

Vitamin E is a fat-soluble vitamin that exists in eight different forms. Each form has its own biological activity, which is the measure of potency or functional use in the body . Alpha-tocopherol (α-tocopherol) is the name of the most active form of vitamin E in humans. It is also a powerful biological antioxidant . Vitamin E in supplements is usually sold as alpha-tocopheryl acetate, a form of alpha-tocopherol that protects its ability to function as an antioxidant. The synthetic form is labeled "D, L" while the natural form is labeled "D". The synthetic form is only half as active as the natural form.

Vegetable oils, nuts, green leafy vegetables, and fortified cereals are common food sources of vitamin E in the United States (U.S.). Table 1, Selected Food Sources of Vitamin E, suggests many food sources of vitamin E . Food values are listed in the alpha-tocopherol form of vitamin E.

Who is at risk for vitamin E deficiency?

Vitamin E deficiency is rare in humans. There are three specific situations when a vitamin E deficiency is likely to occur.

1. persons who cannot absorb dietary fat due to an inability to secrete bile or with rare disorders of fat metabolism are at risk of vitamin E deficiency ;
2. individuals with rare genetic abnormalities in the alpha-tocopherol transfer protein are at risk of vitamin E deficiency; and
3. premature, very low birth weight infants (birth weights less than 1500 grams, or 3 pounds, 4 ounces) are at risk of vitamin E deficiency .

Blood levels of vitamin E may also be decreased with zinc deficiency . Vitamin E deficiency is usually characterized by neurological problems associated with nerve degeneration in hands and feet. These symptoms are also associated with other medical conditions. A physician can determine if they are the result of a vitamin E deficiency or are from another cause.

Who may need extra vitamin E to prevent a deficiency?

Individuals who cannot absorb fat require a vitamin E supplement because some dietary fat is needed for the absorption of vitamin E from the gastrointestinal tract. Intestinal disorders that often result in malabsorption of vitamin E and may require vitamin E supplementation include :

• Crohn's Disease is an inflammatory bowel disease that affects the small intestines. People with Crohn's disease often experience diarrhea and nutrient malabsorption.
• Cystic Fibrosis is an inherited disease that affects the lungs, gastrointestinal tract, pancreas, and liver. Cystic fibrosis can interfere with normal digestion and absorption of nutrients, especially of fat soluble vitamins including vitamin E.

People who cannot absorb fat often pass greasy stools or have chronic diarrhea. People with an inability to secrete bile, a substance that helps fat digestion, may need a special water-soluble form of vitamin E.

Abetalipoproteinemia is a rare inherited disorder of fat metabolism that results in poor absorption of dietary fat and vitamin E. The vitamin E deficiency associated with this disease causes problems such as poor transmission of nerve impulses, muscle weakness, and degeneration of the retina that can cause blindness. Individuals with abetalipoproteinemia may be prescribed special vitamin E supplements by a physician to treat this disorder.

Ataxia and vitamin E deficiency (AVED) is also a rare inherited disorder. It is caused by a genetic defect in a liver protein that is responsible for maintaining normal alpha-tocopherol concentrations in the blood. These individuals have such severe vitamin E deficiency that without supplements they are unable to walk (ataxia).

Very low birth weight infants may be deficient in vitamin E. Necrotizing enterocolitits, a condition sometimes seen in very low birth weight infants that is characterized by inflammation of the lining of the intestines, may lead to a vitamin E deficiency. These infants are usually under the care of a neonatologist, a pediatrician specializing in the care of newborns who evaluates and treats the exact nutritional needs of premature infants.

Gerovital H3 Injection & Gerovital Tablets

Gerovital

Non Placental Anti-aging Therapy
Procaine Hydrochloride

Introduction:

Based on Procaine, Gerovital H3 (or GH3 on short), has been discovered by a Romanian doctor, Prof. Dr Ana Aslan at the National Geriatric Institute in Bucharest, the capital City of Romania, in early fifties.

Being the first anti-aging therapy, Aslan's GH3 reduces free radical activity preventing damage to DNA and cellular membrane. The enhanced cellular bioenergetics optimizes ATP, the body's universal energy molecule. It also normalizes brain neuro-transmitting balance to help normalize chronobiological rhythms.

How it works to protect our cells?

Professor Aslan, the procaine founder, has concluded that Gerovital H3 (or GH3) works at ‘the cellular level’ in our body. The process of cell cycle when a person grows is:

After birth – Proliferation of new cells and some cells commence to die. The body entirely undergoes differentiation of cellular organization or getting more complex.

Age of twenties – Formation of new cells and the dying of old ones is in a balance state.

Age of thirties – A person is losing more cells than they are gaining and there is a decline in overall health condition and efficiency. At this age, the entire body or brain function begins to deteriorate.

Procaine hydrochloride, being the active ingredient in GH3 consisting of two substances that found naturally in the body. So, at a glance it is not belongs to any pharmaceutical drugs which cause undesirable side effects. The two substances, namely PABA and DEAE are belonging to the group of Vitamin B complex. When combined with these two substances are infinitely more beneficial than their separate parts and this in fact gave rise to the description ‘H3’ which was coined to describe the powerful factor in the procaine molecule. When procaine molecules break down into its constituent parts (PABA and DEAE) in intestine, these ingredients are absorbed and play vitally important roles prior to final metabolism.

PABA stimulates beneficial intestinal flora to produce vitamin K and B and also essential Folic Acid, while DEAE helps generate choline and acetycholine essential for the effective functioning of the spleen, liver, brain and nerve synapses. By working at the cellular level GH3 has been seen to have the ability to influence both body and brain in a wide variety of ways. Also, it increases the oxygen content of the red corpuscles up to 30%. Essentially this strengthens the immune systems and resistance to infection of any type.

Patients who treated with GH3 at some period of time have been observed to respond beneficially on the following diseases/disorders/ailments:

Arthritis

Migraine

Abnormal blood pressure

Peptic ulcers

Acne or pimples

Parkinson’s disease

Hodgkinson’s disease

Multiple sclerosis

Arteriosclerosis

Sickle cell anemia

Hypoglycemia

Hypertension

Hypotension

Diabetes

Herpes

Bad circulatory system

Heart disease

Angina pectoris

Osteoporosis

Impotence

Frigidity

Liver spots

Varicose veins

Grey hair and balding

Wrinkles and fine lines

Asthenia

Edema

Emphysema

Neuralgia

Excessive cholesterol, and

Aging ailments such as decreased sexual desire, tiredness, erectile dysfunction, depressions, and common cough and cold

Composition:

Procaine Hydrochloride
=0.1000g

Benzoic Acid
=0.0060g

Potassium Metabisulfite
=0.0050g

Disodium Phosphate
=0.0005g

Packing:

5 x 5ml

10 x 5ml

Contraindication:

Specific allergy to procaine

Adverse reactions:

No adverse reactions have been recorded. With procaine sensitive persons, the following phenomena may however appear; cephalea, shaking, bradycardia or tachycardia, motor or psychic restlessness, allergic reactions.

Incompatibility:

Gerovital H3 should not be administered simultaneously with sulphonamides (inactivation), eserine or prostigmine.

Dosage:

Parentally - 1 intramuscular injection three times a week, over a period of 4 weeks. The treatment should be repeated after an intermission of 1 to 2 months.

C-Reactive Protein (CRP) CRP 1000

Vitamin C +Kollagen Smitch

Vitamin C +Kollagen

Packing:

5 x 5ml of Vitamin C + collagen

Vitamin C (Ascorbic Acid) 1000mg

Fibrous Collagen 375mg

Method:

By I.V.(Intravenous)

1 box = 1 course continuous effect

Modes of action:

Collagen is found naturally in human skin layer for scaffolding our skin structures. It provides support, and gives the young firm/smooth skin. When we are aged we loose the ability to produce more collagen and hence lost of elasticity, appearance of wrinkles/fine lines occurred. The benefits we derived from injectable collagen is:

• To smooth out wrinkles and fine lines around the area of eyes, face, chin and body skin

• To increase the volume of lips

• To elevate scars and depression

• To prevent sagging breast and buttock

How Collagen is injected:

It is injected through a small needle just underneath the skin or by intravenously (I.V.) If redness develops it will diminish in a few hours. Patient can continue their normal activities daily.

How Long does Collagen Last?

Initial injected of collagen will last for four-six months. The collagen will be gradually absorbed into the body and metabolized. Continuous treatment of collagen injections within interval can make the collagen last longer.

Why Vitamin C added?

Collagen is the most ubiquitous substance ad found mostly abundance of fibers in connective tissues of human skin. Connective tissues that is giving us the support, firmer, smoother and suppler skin. Also, collagen does support our organs, building of tendons, bones, ligaments, etc.

When collagen is produced, there is a complex series of events that involving the vitamin C. It helps to form the precursor molecule called procollagen, and later to be packaged/modified into collagen. Without vitamin C/ascorbic acid, the production of collagen will be disrupted. That is why vitamin C is added along with collagen injections.

Any side effect of collagen injections?

The side effect of collagen is those who suffer from allergic after taking the injection. The allergic may appear as red, tender bumps and cause ulcering. This phenomenon will last only for few months. Over 100 patients, 2 will experience the side effect of collagen. The product has using a suitable amount of collagen to minimize side effects.

Dosage:

The injections of vitamin C + collagen can be introduced one ampoule every three (3) days.