Vitamin B2

International generic name

Riboflavin

Drug form and composition

Solution for injection. One ampoule of 2 ml contains Riboflavine Sodium Phosphate equ. to 10 mg Riboflavin (5 mg/ml).

Indications

Lack of vitamin B2, when oral treatment is not enough effective in following conditions: burning; chronic febrile states; gastrectomy; liver and biliary ducts diseases (alcoholism with cirrhosis, obstructive jaundice), hyperthyroidism; prolonged infections; intestinal diseases (tropical sprue, enteritis, persistent diarrhea); malignant tumors; prolonged stress.

Dosage and administration

The drug is used by parenteral route (intramuscularly or intravenously) in a daily dose - 5 to 20 mg. The treatment course depends on the severity of the disease. After getting control of the clinical picture the treatment can be continued by oral drug administration.

Contraindications

Hypersensitivity to the preparation.

Special warnings and precautions

Because of different types of incompatibility, administration in one syringe is unallowable with: benzylpenicillin and oxacillin (antibiotic inactivation and precipitation); macrolides (formation of unsoluble sediment); chloramphenicol (precipitation); vitamin B1 (vitamin B1 oxidation); vitamin B12 (vitamin B2 destruction by the cobalt ions); vitamin C (vitamin B2 inactivation).

Drug interactions

No clinically significant adverse drug reactions in cases of concurrent administration of vitamin B2 with other drugs have been reported.

Adverse reactions

In some cases, pain in the place of drug application can be observed. After administration of high doses hypergranulate (changes in oral mucosa) can occur.

Pharmacological mechanisms

Vitamin B2 is widespread in the nature. It has also been produced synthetically. The vitamin enters in the body predominantly with the food (beer, liver, eggs, meat, fish, milk, wheat germs, etc.) It plays role in the oxidation-reduction reactions in the body. After entering in the organism vitamin B2 interacts with adenosine triphosphate acid and forms nucleotide compounds, which represent coenzymes of flavin proteins, participating in the transmission of the hydrogen ions and in the regulation of the oxidation-reduction reactions. It facilitates carbohydrate metabolism, improves disturbed lipid metabolism, and it is related to the metabolism of the amine acids. Vitamin B2 influences the iron and porphyrin metabolism, hemoglobin synthesis, and cellular breathing.

Supplied

10 or 100 ampoules of 2 ml (10 mg).